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High-performance bioinspired microspheres for boosting dental adhesion
Yao, C.; Liang, S.J.; Yu, M.Y.; Wu, H.L.; Ahmed, M.H.; Liu, Y.H.; Yu, J.; Zhao, Y.; Van der Bruggen, B.; Huang, C.; Van Meerbeek, B. (2024). High-performance bioinspired microspheres for boosting dental adhesion. Small Early View: 2310251.
In: Small. Wiley-VCH GmbH: Weinheim. ISSN 1613-6810; e-ISSN 1613-6829, more
Peer reviewed article  

Available in  Authors 

Author keywords
    bio-interface; dental adhesive; metal-ion chelation; polydopamine; synergistic effect

Authors  Top 
  • Yao, C., more
  • Liang, S.J.
  • Yu, M.Y.
  • Wu, H.L.
  • Ahmed, M.H., more
  • Liu, Y.H.
  • Yu, J.
  • Zhao, Y., more
  • Van der Bruggen, B., more
  • Huang, C.
  • Van Meerbeek, B.


    Dental adhesives are widely used in daily practice for minimally invasive restorative dentistry but suffer from bond degradation and biofilm attack. Bio-inspired by marine mussels having excellent surface-adhesion capability and high chemical affinity of polydopamine (PDA) to metal ions, herein, experimental zinc (Zn)-containing polydopamine-based adhesive formulation, further being referred to as “Zn–PDA@SiO2”-incorporated adhesive is proposed as a novel dental adhesive. Different Zn contents (5 and 10 mm) of Zn–PDA@SiO2 are prepared. Considering the synergistic effect of Zn and PDA, Zn–PDA@SiO2 not only presents excellent antibacterial potential and notably inhibits enzymatic activity (soluble and matrix-bound proteases), but also exhibits superior biocompatibility and biosafety in vitro/vivo. The long-term bond stability is substantially improved by adding 5 wt% 5 mm Zn–PDA@SiO2 to the primer. The aged bond strength of the experimentally formulated dental adhesives applied in self-etch (SE) bonding mode is 1.9 times higher than that of the SE gold-standard adhesive. Molecular dynamics calculations indicate the stable formation of covalent bonds, Zn-assisted coordinative bonds, and hydrogen bonds between PDA and collagen. Overall, this bioinspired dental adhesive provides an avenue technology for innovative biomedical applications and has already revealed promising perspectives for dental restorative dentistry.

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