IMIS | Lifewatch regional portal

You are here


[ report an error in this record ]basket (0): add | show Print this page

Emerging pharmaceutical therapies of Ascidian-derived natural products and derivatives
Cooreman, K.; De Spiegeleer, B.; Van Poucke, C.; Vanavermaete, D.; Delbare, D.; Wynendaele, E.; De Witte, B. (2023). Emerging pharmaceutical therapies of Ascidian-derived natural products and derivatives. Environ. Toxicol. Pharmacol. 102: 104254.
In: Environmental Toxicology and Pharmacology. Elsevier: Amsterdam; Lausanne; New York; Oxford; Shannon; Tokyo. ISSN 1382-6689; e-ISSN 1872-7077, more
Peer reviewed article  

Available in  Authors 

    Ascidiacea [WoRMS]
Author keywords
    Anticancer treatment; Ascidian metabolites; Bioactive substances; Drug development; Mechanism of action; Symbiosis

Authors  Top 
  • Cooreman, K., more
  • De Spiegeleer, B., more
  • Van Poucke, C., more
  • Vanavermaete, D., more

    In a growing multidrug-resistant environment, the identification of potential new drug candidates with an acceptable safety profile is a substantial crux in pharmaceutical discovery. This review discusses several aspects and properties of approved marine natural products derived from ascidian sources (phylum Chordata, subphylum Tunicata) and/or their deduced analogues including their biosynthetic origin, (bio)chemical preclinical assessments and known efficacy-safety profiles, clinical status in trials, but also translational developments, opportunities and final conclusions. The review also describes the preclinical assessments of a large number of other ascidian compounds that have not been involved in clinical trials yet. Finally, the emerging research on the connectivity of the ascidian hosts and their independent or obligate symbiotic guests is discussed. The review covers the latest information on the topic of ascidian-derived marine natural products over the last two decades including 2022, with the majority of publications published in the last decade.

All data in the Integrated Marine Information System (IMIS) is subject to the VLIZ privacy policy Top | Authors