Anticonvulsant and analgesic activities of crude extract and its fractions of the defensive secretion from the Mediterranean sponge, Spongia officinalis
Dellai, A.; Ben Mansour, H.; Clary-Laroche, A.; Deghrigue, M.; Bouraoui, A. (2012). Anticonvulsant and analgesic activities of crude extract and its fractions of the defensive secretion from the Mediterranean sponge, Spongia officinalis. Cancer Cell International 12(1): 15. https://dx.doi.org/10.1186/1475-2867-12-15
In: Cancer Cell International. BMC: London. e-ISSN 1475-2867, more
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| Keywords |
Spongia (Spongia) officinalis Linnaeus, 1759 [WoRMS]
Marine/Coastal |
| Authors | | Top | Dataset |
- Dellai, A.
- Ben Mansour, H.
- Clary-Laroche, A.
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- Deghrigue, M.
- Bouraoui, A.
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| Abstract |
This study progresses in the direction of identifying component(s) from the Mediterranean sponge, Spongia officinalis with anticonvulsant and analgesic activities. We investigated the efficacy of crude extract and its semi-purified fractions (F1-F3) of the defensive secretion from Spongia officinalis for their in vivo anticonvulsant activity using the pentylenetetrazole (PTZ) seizure model and analgesic activity using the writhing test in mice. Among the series the crude extract exhibited interesting analgesic activity in a dose dependent manner. Similarly the fraction F2 showed a partial protection of mice from PTZ-induced seizure and interesting analgesic activity in a dose dependent manner. The purification and the determination of chemical structure(s) of compound(s) of this active fraction are under investigation. |
| Dataset |
- CorMedNet- Distribution and demographic data of habitat-forming invertebrate species from Mediterranean coralligenous assemblages between 1882 and 2019., more
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