Antifouling properties of simple indole and purine alkaloids from the Mediterranean gorgonian Paramuricea clavata
Penez, N.; Culioli, G.; Pérez, T.; Briand, J.-F.; Thomas, O.P.; Blache, Y. (2011). Antifouling properties of simple indole and purine alkaloids from the Mediterranean gorgonian Paramuricea clavata. J. Nat. Prod. 74(10): 2304-2308. https://dx.doi.org/10.1021/np200537v
In: Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington DC. ISSN 0163-3864; e-ISSN 1520-6025, more
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| Authors | | Top | Dataset |
- Penez, N.
- Culioli, G.
- Pérez, T.
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- Briand, J.-F.
- Thomas, O.P.
- Blache, Y.
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| Abstract |
Chemical investigation of the Mediterranean gorgonian Paramuricea clavata resulted in the isolation of two new alkaloids, 2-bromo-N-methyltryptamine (1) and 3-bromo-N-methyltyramine (2), together with nine known compounds (3–10 and linderazulene). The bromoindole derivative 3 is reported herein for the first time from a natural source. The chemical structures of these compounds were assigned by spectroscopic analyses and comparison with literature values. The antifouling activity and toxicity of compounds 1–10 were assessed using three marine biofilm bacteria and the Microtox assay. In contrast to commercial antifoulants, bufotenine (5) and 1,3,7-trimethylisoguanine (10) showed significant antiadhesion activity against one bacterial strain while being nontoxic. |
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- CorMedNet- Distribution and demographic data of habitat-forming invertebrate species from Mediterranean coralligenous assemblages between 1882 and 2019., more
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